Macrolids a prosztatitis kezelésében. Publication types
DOI: Regulatory agencies warn that these antibiotics increase the prostatitis exacerbations of ventricular arrhythmia. We examined the day risk of ventricular arrhythmia and all-cause mortality associated with macrolide antibiotics relative to nonmacrolide antibiotics.
Our primary outcome was a hospital encounter with ventricular arrhythmia within 30 days after a new prescription.
Our secondary outcome was day all-cause mortality. We matched patients using propensity scores to patients prescribed nonmacrolide antibiotics amoxicillin, cefuroxime or levofloxacin.
We used conditional logistic regression to measure the association between macrolide exposure and outcomes, and repeated the analysis in 4 subgroups defined by the presence or absence of chronic kidney disease, congestive heart failure, coronary artery disease and concurrent use of a drug known to prolong the QT interval.
Results: Compared with nonmacrolide antibiotics, macrolide antibiotics were not associated with a higher risk of ventricular arrhythmia 0.
These associations were similar in all subgroups. Interpretation: Among older adults, macrolide antibiotics were not associated with a higher day risk of ventricular arrhythmia than nonmacrolide antibiotics. These findings suggest that current warnings from the US Food and Drug Administration may be overstated.