Macrolids a prosztatitis kezelésében. Publication types

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DOI: Regulatory agencies warn that these antibiotics increase the prostatitis exacerbations of ventricular arrhythmia. We examined the day risk of ventricular arrhythmia and all-cause mortality associated with macrolide antibiotics relative to nonmacrolide antibiotics.

Our primary outcome was a hospital encounter with ventricular arrhythmia within 30 days after a new prescription.

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Our secondary outcome was day all-cause mortality. We matched patients using propensity scores to patients prescribed nonmacrolide antibiotics amoxicillin, cefuroxime or levofloxacin.

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We used conditional logistic regression to measure the association between macrolide exposure and outcomes, and repeated the analysis in 4 subgroups defined by the presence or absence of chronic kidney disease, congestive heart failure, coronary artery disease and concurrent use of a drug known to prolong the QT interval.

Results: Compared with nonmacrolide antibiotics, macrolide antibiotics were not associated with a higher risk of ventricular arrhythmia 0.

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These associations were similar in all subgroups. Interpretation: Among older adults, macrolide antibiotics were not associated with a higher day risk of ventricular arrhythmia than nonmacrolide antibiotics. These findings suggest that current warnings from the US Food and Drug Administration may be overstated.

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