Insulin-like growth factor mRNA-binding protein 3 IMP3 is an oncofetal protein found to be re-expressed in a series of human cancers including bladder cancer. In vitro analyses showed an invasion and proliferation promoting effect for IMP3.
However, this molecular interaction has not yet been analysed in tumour samples. In the present study, we identified for the first time high IMP3 tissue protein expression as an independent predictor of poor patients' survival in muscle-invasive bladder cancer.
Furthermore, there was no correlation between IMP3 and its molecular targets in bladder carcinoma specimens and concluded that the tumour-promoting effect of IMP3 is not related to its regulatory action on IGF2 and CD Expression levels were correlated with clinical follow-up data by using both univariate and multivariate Cox regression analyses.
In muscle-invasive BC IMP3 protein but not gene expression proved to be an independent predictor of disease-specific hazard ratio [HR] 2. Its high expression in high-grade bladder carcinoma cells makes IMP3 for an attractive target for therapy.